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EPZ015666, PRMT5 inhibitor, 5mg, CAS# 1616391-65-1

EPZ015666, PRMT5 inhibitor, 5mg, CAS# 1616391-65-1

Tazemetostat, EZH2 inhibitor, 5mg, CAS# 1403254-99-8

Tazemetostat, EZH2 inhibitor, 5mg, CAS# 1403254-99-8

Tazemetostat, EZH2 inhibitor, 25mg, CAS# 1403254-99-8

$175.00
N-((4,6-Dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-4-methyl-4’-(morpholinomethyl)-[1,1’-biphenyl]-3-carboxamide Purity: 98% Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-4032-25mg-EA
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Tazemetostat, EZH2 inhibitor, 25mg, CAS# 1403254-99-8 is available to buy in increments of 1

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Tazemetostat is a potent (Ki = 2.5nM wild type human PRC2-containing) and selective SAM-competitive inhibitor of the lysine methyltransferase EZH2.1 Tazemetostat displayed strong antiproliferative effects against SMARCB1-deleted malignant rhabdoid tumor (MRT) cell lines in vitro. This antitumor activity was also observed in SMARTCB1 mutant mouse xenografts. It displayed potent antitumor activity in various cancer models including non-Hodgkins lymphoma2, pediatric glioma3, small-cell carcinoma of the ovary4, and synovial sarcomas5. Tazemetostat has also been shown to control inflammatory genes by modulating IRF1, IRF8, and STAT1 levels suggesting therapeutic potential for the treatment of neuroinflammatory diseases associated with microglial activation.6

CAS Number: 1403254-99-8

Manufacturer Part Number/SKU: 10-4032-25mg-EA

Tags: Focus Biomolecules