SR0987, RORγt agonist, 5mg, CAS# 303126-97-8
$65.00
2-Chloro-N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]benzamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4008-5mg-EA
SR0987, RORγt agonist, 5mg, CAS# 303126-97-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsRORγt is a T cell specific isoform of ROR that is a key transcription factor for initiating the differentiation of Th17 and Tc17 cells. SR0987 (303126-97-8) is a RORγt agonist that drives proliferation of Th17 cells and decrease levels of the immune checkpoint protein PD-1. In a Ga14 UAS-Luc cotransfection system, SR0987 induced reporter gene expression (EC50 = 800nM). Treatment of human Jurkat T cells with SR0987 resulted in decreased cell surface PD-1 expression. RORγt agonists may synergize with current anti-PD-1 therapy and represent a new potential class of cancer immunotherapeutic.
CAS Number: 303126-97-8
Manufacturer Part Number/SKU: 10-4008-5mg-EA
Tags: Focus Biomolecules