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RITA, p53 activator, 25mg, CAS# 213261-59-7

RITA, p53 activator, 25mg, CAS# 213261-59-7

PCI-34051, HDAC8 inhibitor, 25mg, CAS# 950762-95-5

PCI-34051, HDAC8 inhibitor, 25mg, CAS# 950762-95-5

GSK126, EZH2 methyltransferase inhibitor, 25mg, CAS# 1346574-57-9

$325.00
N-[(1,2-Dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide Purity: 98% by HPLC/TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-3394-25mg-EA
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GSK126, EZH2 methyltransferase inhibitor, 25mg, CAS# 1346574-57-9 is available to buy in increments of 1

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Potent, selective, S-adenosyl-methionine-competitive inhibitor of EZH2 methyltransferase, Ki=0.5-3 nM, >150-fold selective for EZH2 over EZH1 and >1000-fold selective over 20 methyltransferases.1 Decreases global H3K27me3 levels and reactivates silenced PRC2 target genes. GSK-126 inhibits proliferation of diffuse large B-cell lymphoma (DLBCL) cell lines as well as DLBCL xenografts in mice.1 Rescues exhausted CD8+ T cells in HCV infection.2 Facilitates the transition of embryonic stem cells to feeder-free extended pluripotent stem cells in combination with a cocktail of other agents.3 Displays neuroprotective effects in ischemic brain injury in a rodent model.4

CAS Number: 1346574-57-9

Manufacturer Part Number/SKU: 10-3394-25mg-EA

Tags: Focus Biomolecules