AS-8351, KDM5B histone demethylase inhibitor, 5mg, CAS# 796-42-9
$50.00
2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone Purity: 98% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1597-5mg-EA
AS-8351, KDM5B histone demethylase inhibitor, 5mg, CAS# 796-42-9 is available to buy in increments of 1
Product Details
Download Details and SpecificationsAS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1
CAS Number: 796-42-9
Manufacturer Part Number/SKU: 10-1597-5mg-EA
Tags: Focus Biomolecules