AGI-5198, R132 mutant isocitrate dehydrogenase inhibitor, 25mg, CAS# 1355326-35-0
$95.00
N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide Purity: 98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4599-25mg-EA
AGI-5198, R132 mutant isocitrate dehydrogenase inhibitor, 25mg, CAS# 1355326-35-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsAGI-5198 is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1(IDH1).1 It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2 This mutation results in loss-of-function for oxidative decarboxylation of isocitrate and gain-of-function for production of the oncometabolite R-2-hydroxyglutarate (R-2HG) form alpha-ketoglutarate (2-OG).
CAS Number: 1355326-35-0
Manufacturer Part Number/SKU: 10-4599-25mg-EA
Tags: Focus Biomolecules