UCB9608, Highly selective PI4KIIIß inhibitor, 25mg, CAS# 1616413-96-7
$335.00
(3S)-4-(6-Amino-1-methylpyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamide Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4857-25mg-EA
UCB9608, Highly selective PI4KIIIß inhibitor, 25mg, CAS# 1616413-96-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsUCB9608 is a potent (IC50 = 5 nM), highly selective, and orally bioavailable inhibitor of the phosphatidylinositol kinase PI4KIIIß.1 It acts as a potent immunosuppressive agent (IC50 = 37 nM human mixed lymphocyte reaction (HuMLR) assay) and was able to significantly prolong heterotopic allograft retention in a mouse model of cardiac allograft rejection. UCB9608 preserved graft tolerance in mice carrying a heterotopic allogenic heart challenged with host-type melanoma and subsequently treated with antitumor immunotherapy.2 UCB9608 promoted a T cell regulatory phenotype over an effector phenotype.3
CAS Number: 1616413-96-7
Manufacturer Part Number/SKU: 10-4857-25mg-EA
Tags: Focus Biomolecules