AR7, Activates chaperone mediated autophagy, 25mg, CAS# 80306-38-3
$280.00
7-Chloro-3-(4-methylphenyl)-2H-1,4-benzoxazine Purity: 98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5515-25mg-EA
AR7, Activates chaperone mediated autophagy, 25mg, CAS# 80306-38-3 is available to buy in increments of 1
Product Details
Download Details and SpecificationsAtypical retinoid which acts as an RARα antagonist and activates chaperone-mediated autophagy (CMA) via an RAR-dependent pathway.1 Downstream signaling results in an increase of LAMP-2A expression.1 Cells pretreated with AR7 had markedly improved viability in a paraquat-induced oxidative stress model.1 AR7 stimulated CMA and attenuated accumulation of SNCA oligomers in prolonged cultures of mutant cortical neurons2 indicating that CMA activation may be a viable disease modifying strategy in Parkinson's disease3. A targetome analysis of AR7-induced CMA in cancer cells has been performed.4
CAS Number: 80306-38-3
Manufacturer Part Number/SKU: 10-5515-25mg-EA
Tags: Focus Biomolecules