SU9516, CDK inhibitor (pan-specific), 5mg, CAS# 377090-84-1
$75.00
(Z)-1,3-Dihydro-3-(1H-imidazol-4-ylmethylene)-5-methoxy-2H-2-one Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5705-5mg-EA
SU9516, CDK inhibitor (pan-specific), 5mg, CAS# 377090-84-1 is available to buy in increments of 1
Product Details
Cyclin-dependent kinase inhibitor, IC50s= 0.02-0.03, 0.04-0.2, 0.2-1.7 and 0.9 µM for cdk2, cdk1, cdk4, cdk9 respectively.1,2 Inhibits phosphorylation of retinoblastoma protein pRb, causing enhanced pRb/E2f complex formation, cell cycle arrest at G1 and G2-M and apoptosis.3 Down-regulates antiapoptotic protein Mcl-1 expression resulting in mitochondrial injury and cell death.4 Inhibits epithelial-mesenchymal transition (IC50=1.21 µM) a crucial pathological event in tumor cell budding and metastasis.5 Cell permeable.
CAS Number: 377090-84-1
Manufacturer Part Number/SKU: 10-5705-5mg-EA
Tags: Focus Biomolecules