BAY-876, GLUT1 inhibitor, 5mg, CAS# 1799753-84-6
$80.00
N4-[1-(4-Cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4708-5mg-EA
BAY-876, GLUT1 inhibitor, 5mg, CAS# 1799753-84-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPotent inhibitor (IC50 = 2 nM) of the facilitative glucose transporter GLUT1, an enzyme frequently overexpressed in many cancers.1 It shows greater than 100-fold selectivity over GLUT2-4. BAY-876 displayed potent antitumor activity in ovarian cancer xenograft models2 and in triple negative breast cancer cells displaying high glycolytic and low oxidative phosphorylation rates3. It reduced CD4+ T cell proliferation and IFN-γ secretion via GLUT1 inhibition suggesting utility against auto-inflammatory diseases.4 BAY-876 induces disulfidptosis in SLCA11high cancer cells.5
CAS Number: 1799753-84-6
Manufacturer Part Number/SKU: 10-4708-5mg-EA
Tags: Focus Biomolecules