SR-1001, RORag inverse agonist, 5mg, CAS# 1335106-03-0
$76.00
N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide Purity: 98% by TLC Purity: NMR (conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1290-5mg-EA
SR-1001, RORag inverse agonist, 5mg, CAS# 1335106-03-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity1. It inhibits the development of murine TH17 cells2 and suppresses the expression of cytokines1. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model3. Protects against pathologic neovascularization in various mouse models of retinopathy4. Active in vivo
CAS Number: 1335106-03-0
Manufacturer Part Number/SKU: 10-1290-5mg-EA
Tags: Focus Biomolecules