P22077, USP7 inhibitor, 10mg, CAS# 1247819-59-5
$70.00
1-(5-((2,4-Difluorophenyl)thio)-4-nitrothiophen-2-yl)ethanone Purity: 98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4125-10mg-EA
P22077, USP7 inhibitor, 10mg, CAS# 1247819-59-5 is available to buy in increments of 1
Product Details
Download Details and SpecificationsP22077 is a selective (tested against 23 other DUBs) inhibitor of USP7 (IC50 = 8 µM) and the closely related USP47.1,2 It destabilizes claspin, a scaffolding protein involved in regulating Chk1 kinase, a DNA damage response enzyme.2 P22077 inhibits neuroblastoma growth via induction of p53-mediated apoptosis.3 N-Myc was destabilized by P22077 inhibition of USP7 in human neuroblastoma cells.4 It was able to stabilize p53 levels in conjunction with an Mdm2 inhibitor (Nutlin-3, Cat# 10-1350) in HCT116 colorectal carcinoma cells.5
CAS Number: 1247819-59-5
Manufacturer Part Number/SKU: 10-4125-10mg-EA
Tags: Focus Biomolecules