SGI-1027, DNA methyl transferase inhibitor, 5mg, CAS# 1020149-73-8
$70.00
N-[4-[(2-Amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)benzamide Purity: 98% by TLC NMR (Conforms) Store -20°C Ship Rt (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5488-5mg-EA
SGI-1027, DNA methyl transferase inhibitor, 5mg, CAS# 1020149-73-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPotent and selective inhibitor of DNA methyl transferase inhibiting DNMT1, DNMT3A and DNMT3B with comparable potency (IC50=12.5, 8.0 and 7.5 mM respectively).1 Treatment of various cancer cell lines with SGI-1027 results in selective degradation of DNMT1 (MG-132 sensitive) with minimal effect on DNMT3A and 3B at 2.5-5 mM.1 Prolonged treatment of RKO cells resulted in reexpression of silenced tumor suppressor genes.1 Synergizes with doxorubicin at growth inhibition in neuroblastoma cell lines.2 Disrupts the MKK3-MYC complex in cells and inhibits MYC transcriptional activity in colon and breast cancer cells.3
CAS Number: 1020149-73-8
Manufacturer Part Number/SKU: 10-5488-5mg-EA
Tags: Focus Biomolecules