SB-525334, ALK5 (TGFβR1) inhibitor, 5mg, CAS# 356559-20-1
$60.00
6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2983-5mg-EA
SB-525334, ALK5 (TGFβR1) inhibitor, 5mg, CAS# 356559-20-1 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPotent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model1. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis2. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine3. Cell permeable and active in vivo.
CAS Number: 356559-20-1
Manufacturer Part Number/SKU: 10-2983-5mg-EA
Tags: Focus Biomolecules