RITA, p53 activator, 5mg, CAS# 213261-59-7
$70.00
5,5'-(2,5-Furandiyl)bis-2-thiophenemethanol Purity: 98% by TLC NMr (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3385-5mg-EA
RITA, p53 activator, 5mg, CAS# 213261-59-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsRITA (reactivation of p53 and induction of tumor cell apoptosis) binds to p53 (Kd = 1.5 nM), changing its conformation, preventing it from binding to HDM2 (human ortholog of MDM2, Mouse Double-Minute clone 2), and targeting it for proteasomal degradation.1 It also weakly (computed Kd = 22 µM) binds HDM2 in the cleft that contacts the p53 transactivation domain.2 Its restoration of mutant p53 function depends on eIF2α phosphorylation, and it induces apoptosis via p53-dependent and -independent (JNK/SAPK/p38; protein translation) pathways.3-5 Induces senescence in head and neck cancer cells.6
CAS Number: 213261-59-7
Manufacturer Part Number/SKU: 10-3385-5mg-EA
Tags: Focus Biomolecules