Pomalidomide, Cereblon ubiquitination inhibitor, 100mg, CAS# 19171-19-8
$150.00
1,3-Dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline; 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide Purity: 98% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2768-100mg-EA
Pomalidomide, Cereblon ubiquitination inhibitor, 100mg, CAS# 19171-19-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsThalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 mM for CRBN-DDB1 complex.1 Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNFa and IL-2.2 Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.3 Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS.4,5
CAS Number: 19171-19-8
Manufacturer Part Number/SKU: 10-2768-100mg-EA
Tags: Focus Biomolecules