PF-670462 dihydrochloride, Casein kinase 1δ/ε inhibitor, 5mg, CAS# 950912-80-8
$70.00
4-[3-Cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine 2HCl Purity: >98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4692-5mg-EA
PF-670462 dihydrochloride, Casein kinase 1δ/ε inhibitor, 5mg, CAS# 950912-80-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPotent inhibitor of casein kinase 1ε/δ (CK1ε, IC50 = 7.7 nM; CK1δ, IC50 = 14 nM).1 It is a circadian clock modifier that caused robust phase delays in rats1 and Cynomolgus monkeys2. PF-670462 caused nuclear retention of the clock protein PER resulting in period lengthening in a phase-specific manner that was dependent on CK1δ inhibition and not CK1ε.3 It improved cognitive performance and reduced amyloid load in various mouse models of Alzheimer's disease.4-6 PF-670462 slowed the progression of and increased survival of chronic lymphocytic leukemia in mice alone and in combination with Ibrutinib.7
CAS Number: 950912-80-8
Manufacturer Part Number/SKU: 10-4692-5mg-EA
Tags: Focus Biomolecules