GSK3326595, PRMT5 inhibitor, 25mg, CAS# 1616392-22-3
$195.00
6-[(1-Acetylpiperidine-4-yl)amino]-N-[(2S)-3-(3,4-dihydro-1H-isoquinolin-2-yl)-2-hydroxypropyl]pyrimidine-4-carboxamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4028-25mg-EA
GSK3326595, PRMT5 inhibitor, 25mg, CAS# 1616392-22-3 is available to buy in increments of 1
Product Details
Download Details and SpecificationsGSK3326595 is a potent (IC50 = 6.2nM), selective (>4000-fold over 20 other methyltransferases), SAM uncompetitive, peptide competitive inhibitor of PRMT5.1 PRMT5 inhibition activated the p53 pathway via induction of alternative splicing of MDM4 leading to a potent anti-proliferative response both in vitro and in vivo. Combination therapy with palbociclib (CDK4/6 inhibitor, Focus Cat.# 10-4760) and GSK3326595 lead to increased efficacy of palbociclib in treating native and resistant models of melanoma via regulation of the PRMT5-MDM4 axis.2 Currently in clinical Trials.3
CAS Number: 1616392-22-3
Manufacturer Part Number/SKU: 10-4028-25mg-EA
Tags: Focus Biomolecules