PF-06840003, IDO1 inhibitor, 50mg, CAS# 198474-05-4
$210.00
3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dione Purity: 98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4498-50mg-EA
PF-06840003, IDO1 inhibitor, 50mg, CAS# 198474-05-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPF-06840003 (198474-05-4) is a potent (IC50 = 150 and 410 nM via two methods) and selective inhibitor of Indoleamine-2,3-dioxygenase (IDO1).1 In mice with syngeneic tumor grafts, it reduced intratumoral kynurenine levels by over 80%, inhibited tumor growth as monotherapy, and increased the efficacy of anti-PD-L1 therapy.2 PF-06840003 treatment combined with GM-CSF-secreting allogenic pancreatic tumor cell vaccine (GVAX) resulted in increased antitumor efficacy in a murine model of pancreatic ductal adenocarcinoma.3
CAS Number: 198474-05-4
Manufacturer Part Number/SKU: 10-4498-50mg-EA
Tags: Focus Biomolecules