Schedule an Appointment
Links
Toggle Nav
Advanced search

CALL US NOW

865-622-5320

Cart 0 Shopping Cart
main product photo
Loading...
Lapatinib_base, EGFR and HER2 inhibitor, 50mg, CAS# 231277-92-2

Lapatinib_base, EGFR and HER2 inhibitor, 50mg, CAS# 231277-92-2

Sorafenib_base, Raf-1 inhibitor (and other kinases), 50mg, CAS# 284461-73-0

Sorafenib_base, Raf-1 inhibitor (and other kinases), 50mg, CAS# 284461-73-0

Pemetrexed, Antifolate; antitumor agent, 10mg, CAS# 357166-29-1

$70.00
N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid Purity: disodium salt Purity: 98% by TLC and HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-2162-10mg-EA
Add to Wish List Add to Compare
Pemetrexed, Antifolate; antitumor agent, 10mg, CAS# 357166-29-1 is available to buy in increments of 1

Product Details

Download Details and Specifications

Pemetrexed is a multi-targeted antifolate with antitumor activity. It potently inhibits folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM).1 A clinically useful anticancer agent.2 Indirectly activates the metabolic kinase AMPK and consequently influences the mTORC1 pathway in human carcinomas.3 Activation of AMPK is associated with pemetrexed resistance.4 Induces G0/G1-phase cell cycle arrest in esophageal squamous cell carcinoma cells.5

CAS Number: 357166-29-1

Manufacturer Part Number/SKU: 10-2162-10mg-EA

Tags: Focus Biomolecules