Sorafenib_base, Raf-1 inhibitor (and other kinases), 50mg, CAS# 284461-73-0
$160.00
4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)phenoxy)-N-methylpicolinamide Purity: 99% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-2174-50mg-EA
Sorafenib_base, Raf-1 inhibitor (and other kinases), 50mg, CAS# 284461-73-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsInitially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50 = 20 nM); PDGFR-β (IC50 = 57 nM); Flt3 (IC50 = 58 nM); c-KIT (IC50 = 68 nM); FGFR-1 (IC50 = 580 nM)1. Paradoxically more potent in a cellular assay (IC50 = 20 nM) compared to an isolated enzyme assay (IC50 = 107 nM) for c-Fms2. Inhibits activation of MAPK pathway and ERK phosphorylation3. Induces caspase-independent apoptosis in melanoma cells4. Clinically useful anticancer agent.
CAS Number: 284461-73-0
Manufacturer Part Number/SKU: 10-2174-50mg-EA
Tags: Focus Biomolecules