PBIT, JARID1 lysine demethylase inhibitor, 25mg, CAS# 2514-30-9
$240.00
2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one Purity: 98% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1595-25mg-EA
PBIT, JARID1 lysine demethylase inhibitor, 25mg, CAS# 2514-30-9 is available to buy in increments of 1
Product Details
Download Details and SpecificationsThe JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.
CAS Number: 2514-30-9
Manufacturer Part Number/SKU: 10-1595-25mg-EA
Tags: Focus Biomolecules