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Propidium_Iodide, Fluorescent stain for dead/dying cells, 50mg, CAS# 25535-16-4

Propidium_Iodide, Fluorescent stain for dead/dying cells, 50mg, CAS# 25535-16-4

UNC0224, G9a histone methyl transferase inhibitor, 5mg, CAS# 1197196-48-7

UNC0224, G9a histone methyl transferase inhibitor, 5mg, CAS# 1197196-48-7

OSS-128167, SIRT6 inhibitor, 5mg, CAS# 887686-02-4

$65.00
5-(3-(Furan-2-carboxamido)benzamido)-2-hydroxybenzoic acid Purity: >98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )

Manufacturer: Focus Biomolecules

SKU
10-5197-5mg-EA
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OSS-128167, SIRT6 inhibitor, 5mg, CAS# 887686-02-4 is available to buy in increments of 1

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OSS-128167 (887686-02-4) is an inhibitor of SIRT6 (IC50=89 µM) showing selectivity over SIRT1 and SIRT2 (IC50s=1,578 and 751 µM, respectively).1 In diffuse large B-cell lymphoma cells which overexpress SIRT6, treatment with OSS-128167 resulted in higher rates of apoptosis, arrested cell cycle progression and augmented sensitivity to chemotherapy.2 It exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress in a streptozotocin-induced diabetic mouse model3 and delays peripheral nerve recovery after injury by suppressing migration, phagocytosis and M2-polarization of macrophages4. OSS-128167 promotes cell senescence and aging in myocardial H9c2 cells.5

CAS Number: 887686-02-4

Manufacturer Part Number/SKU: 10-5197-5mg-EA

Tags: Focus Biomolecules