NVP-231, Ceramide kinase inhibitor, 25mg, CAS# 362003-83-6
$130.00
N-[2-(Benzoylamino)-6-benzothiazolyl]tricyclo[3.3.1.13,7]decane-1-carboxamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4694-25mg-EA
NVP-231, Ceramide kinase inhibitor, 25mg, CAS# 362003-83-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsReversible inhibitor of ceramide kinase (IC50 = 12 nM).1 At 10 nM, it inhibited ceramide-1-phosphate formation by >50% and at 100 nM it completely inhibited its formation in cell culture. NVP-231 was inactive against hSphK1/2, hPI3Ka, hPI4Kb, hVps34, hGCS, hSMS-1, CERT, and 500-fold less potent against hDAGKa. NVP-231 inhibited breast and lung cancer cell proliferation via M phase arrest.2 It potently blocked cell migration and invasion in PANC-1 pancreatic cancer cells3 as well as MDA-MB-231 breast cancer cells4.
CAS Number: 362003-83-6
Manufacturer Part Number/SKU: 10-4694-25mg-EA
Tags: Focus Biomolecules