Nitisinone, Tyrosine metabolism inhibitor, 250mg, CAS# 104206-65-7
$105.00
2-[2-Nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione Purity: >98% by TLC (NMR Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4648-250mg-EA
Nitisinone, Tyrosine metabolism inhibitor, 250mg, CAS# 104206-65-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsInhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.
CAS Number: 104206-65-7
Manufacturer Part Number/SKU: 10-4648-250mg-EA
Tags: Focus Biomolecules