Necrostatin-34, RIP1 kinase inhibitor, 25mg, CAS# 375835-43-1
$285.00
2-[[5-Cyano-4-(4-methylphenyl)-2-oxo-3,4-dihydro-1H-pyridin-6-yl]sulfanyl]-N-(1,3-thiazol-2-yl)acetamide Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4684-25mg-EA
Necrostatin-34, RIP1 kinase inhibitor, 25mg, CAS# 375835-43-1 is available to buy in increments of 1
Product Details
Download Details and SpecificationsNecrostatin-34 is a selective inhibitor of RIP1 kinase. IC50s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 (Focus Cat# 10-4544) locking the enzyme in an inactive conformation. Necrostatin-34 acts synergistically with 7-Cl-O-Nec1 to inhibit necroptosis.
CAS Number: 375835-43-1
Manufacturer Part Number/SKU: 10-4684-25mg-EA
Tags: Focus Biomolecules