Lomitapide, Microsomal triglyceride transfer protein inhibitor, 25mg, CAS# 182431-12-5
$195.00
N-(2,2,2-Trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4664-25mg-EA
Lomitapide, Microsomal triglyceride transfer protein inhibitor, 25mg, CAS# 182431-12-5 is available to buy in increments of 1
Product Details
Download Details and SpecificationsLomitapide is a potent (IC50 = 8 nM) inhibitor of microsomal triglyceride transfer protein (MTP or MTTP) and is clinically useful in treating familial hypercholesterolemia.1,2 It has displayed anticancer activity acting through various pathways including autophagy-dependent cancer cell death via direct inhibition of the kinase activity of mTORC13, activation of AMPK/Beclin1-mediated autophagy4, Notch inhibition via targeting TACE and γ-secretase5, blocking ZDHHC5-dependent palmitoylation on SSTR56, PFKFB3 inhibition7, and PARP14/DRP1-mediated mitophagy8.
CAS Number: 182431-12-5
Manufacturer Part Number/SKU: 10-4664-25mg-EA
Tags: Focus Biomolecules