L6H21, MDL/TLR4 interaction inhibitor, 5mg, CAS# 24533-47-9
$55.00
(2E)-3-(2,3-Dimethoxyphenyl)-1-(4-methoxyphenyl)-2-propen-1-one; (E)-2,3-dimethoxy-4'-methoxychalcone Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5574-5mg-EA
L6H21, MDL/TLR4 interaction inhibitor, 5mg, CAS# 24533-47-9 is available to buy in increments of 1
Product Details
Download Details and SpecificationsL6H21 binds to MD-2 (myeloid differentiation protein-2, Kd=33.3 µM) and blocks its interaction with TLR4 (toll-like receptor 4) in LPS-stimulated cells, inhibiting TNFα and IL-6 production.1 Attenuates disease progression in a high-fat diet (HFD) induced NASH mouse model.2 Inhibits obesity-induced cardiomyopathy and fibrosis.3 Reduces ethanol plus LPS-induced liver injury via inhibition of NLRP3 inflammasome activation.4 Provides cardioprotective effects5 and protects against cognitive impairment and brain pathologies in HFD prediabetic rats6. Cell permeable. Active in vivo.
CAS Number: 24533-47-9
Manufacturer Part Number/SKU: 10-5574-5mg-EA
Tags: Focus Biomolecules