KY-226, PTP1B inhibitor, 25mg, CAS# 1621673-53-7
$240.00
4-(Biphenyl-4-ylmethylsulfanylmethyl)-N-(hexane-1-sulfonyl)benzoylamide Purity: >98% TLC Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4004-25mg-EA
KY-226, PTP1B inhibitor, 25mg, CAS# 1621673-53-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsKY-226 (CAS 1621673-53-7) is a selective allosteric protein tyrosine phosphatase 1B (PTP1B) inhibitor (IC50 = 250 nM) with no activity at PPARγ.1 It significantly reduced plasma glucose, triglyceride, and A1c levels without weight gain in db/db mice.2 It has been suggested that KY-226's anti-diabetic effects occur via enhancements in insulin signaling and anti-obesity effects via leptin signaling enhancements.2 KY-226 has also been shown to protect neurons from cerebral ischemia.3 This effect is mediated by restoration of tight junction proteins via activation of the Akt/FoxO1 pathway.4
CAS Number: 1621673-53-7
Manufacturer Part Number/SKU: 10-4004-25mg-EA
Tags: Focus Biomolecules