Pridopidine, Sigma-1 ligand/neuroprotective/restorative, 25mg, CAS# 346688-38-8

Pridopidine is being studied as a potential treatment for Huntington's disease, Parkinson's disease, and schizophrenia based on its locomotor stabilizing and antipsychotic-like effects.1,2 It was, unusually, able to reverse both hypo- and hyperdopaminergia depending on local dopamine concentrations without inducing catalepsy. This was originally attributed to functional dopamine D2 antagonism with fast on/off kinetics ("dopamine stabilizer").3 More recent studies have attributed pridopidine's effects to its being a more potent sigma-1 ligand than a D2 ligand.4,5 Displays neuroprotective/restorative effects6,7 and ameliorates central features of amyotrophic lateral sclerosis pathology8 in a sigma-1-mediated manner

CAS Number: 346688-38-8

Manufacturer Part Number/SKU: 10-4003-25mg-EA

Tags: Focus Biomolecules