JH-X-119-01, Selective IRAK1 inhibitor, 25mg, CAS# 2227368-54-7
$325.00
N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-5-yl)picolinamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4691-25mg-EA
JH-X-119-01, Selective IRAK1 inhibitor, 25mg, CAS# 2227368-54-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsJH-X-119-01 is a highly selective (significantly inhibited only YSK4 and MEK3 in a panel of over 300 kinases) and potent (IC50 = 9 nM) covalent inhibitor of interleukin 1 receptor-associated kinase 1 (IRAK1). It displayed cytotoxic activity against several lymphoma cell lines and exhibited synergism with the BTK inhibitor Ibrutinib in the same systems. JH-X-119-01 protected mice from LPS-induced sepsis2 and ameliorated acute graft-versus-host disease in mice undergoing allogenic hematopoietic cell transplantation without effecting the anti-lymphoma effect3.
CAS Number: 2227368-54-7
Manufacturer Part Number/SKU: 10-4691-25mg-EA
Tags: Focus Biomolecules