IMR-1, Notch transcriptional activation inhibitor, 5mg, CAS# 310456-65-6
$60.00
2-[2-Methoxy-4-[(4-oxo-2-thioxo-5-thiazolidinylidene)methyl]phenoxy]-acetic acid ethyl ester Purity: 98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3601-5mg-EA
IMR-1, Notch transcriptional activation inhibitor, 5mg, CAS# 310456-65-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsInhibitor of Mastermind Recruitment-1 (IMR-1) disrupts the recruitment of Mastermind-like 1 to the Notch transcriptional activation complex (NTC) on chromatin, which attenuates Notch target gene transcription1. IC50=26 mM (in vitro assay). IMR-1 inhibits the growth of Notch-dependent cell lines and attenuates the growth of patient-derived tumor xenografts. The ethylester is hydrolyzed by intracellular esterases which produces the free acid compound (IMR-1A), IC50=0.5 mM (in vitro assay). Binding of IMR-1 to NTC is non-covalent and reversible.1
CAS Number: 310456-65-6
Manufacturer Part Number/SKU: 10-3601-5mg-EA
Tags: Focus Biomolecules