Honokiol-DCA, TRAP1 inhibitor, 5mg, CAS# 1620160-42-0
$70.00
Honokiol bis-dichloroacetate Purity: >98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3596-5mg-EA
Honokiol-DCA, TRAP1 inhibitor, 5mg, CAS# 1620160-42-0 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA synthetic bis-dichloroacetate ester of the natural product honokiol, is an allosteric inhibitor of the mitochondrial chaperone TRAP1.1 It binds to an allosteric site on TRAP1 leading to inhibition (IC50 ~8mM) and is selective over HSP90, unlike 17-AAG and radicicol which are nonselective. Inhibition of TRAP1 leads to upregulation of succinate dehydrogenase and the mitochondrial deacetylase SIRT3. In neoplastic cells HDCA decreases proliferation, increases mitochondrial superoxide levels and abolishes tumorigenic growth.1 HDCA demonstrated in vivo activity against vemurafenib-resistant (LM36R) melanoma.2
CAS Number: 1620160-42-0
Manufacturer Part Number/SKU: 10-3596-5mg-EA
Tags: Focus Biomolecules