GSK2334470, Potent and selective PDK1 inhibitor, 5mg, CAS# 1227911-45-6
$59.00
(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4725-5mg-EA
GSK2334470, Potent and selective PDK1 inhibitor, 5mg, CAS# 1227911-45-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPotent (IC50 = 10 nM) and selective inhibitor of 3-Phosphoinositide-dependent kinase 1 (PDK1), which phosphorylates and activates a group of protein kinases in the AGC/PKG/PKC family.1 It is more effective at inhibiting PDK1 substrates that are activated in the cytosol rather than at the plasma membrane.1 GSK2334470 delayed melanogenesis and metastasis in Braf(V600E)::Pten(-/-) mice.2 It also displays antitumor activity against multiple myeloma synergistically with mTORC1/2 inhibitor PP2423 and proteasome inhibitor MG-1324.
CAS Number: 1227911-45-6
Manufacturer Part Number/SKU: 10-4725-5mg-EA
Tags: Focus Biomolecules