Idelalisib, Selective PI3Kδ inhibitor, 10mg, CAS# 870281-82-6
$60.00
5-Fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4820-10mg-EA
Idelalisib, Selective PI3Kδ inhibitor, 10mg, CAS# 870281-82-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPotent (IC50 = 2.5nM) and selective (IC50's: PI3Ka = 820nM, PI3Kb = 565nM, PI3Kg = 89nM) PI3Kd inhibitor.1,2 Useful clinical agent for the treatment of various blood cancers. Idelalisib attenuates regulatory T cells (Treg) but not conventional T cells (Tconv) resulting in a significant increase in tumor-infiltrating antigen-specific CD8 T cells in a murine lung cancer model.3 Conversely, systemic PI3Kd inactivation antagonized anti-CTLA-4 and anti-PD-L1 treatment.4 Others have found that Idelalisib minimally influenced rituximab- and obinutuzumab-mediated Ab-dependent cellular cytotoxicity in human lymphoma cells.5
CAS Number: 870281-82-6
Manufacturer Part Number/SKU: 10-4820-10mg-EA
Tags: Focus Biomolecules