Volasertib, Polo-like Kinase 1 inhibitor, 5mg, CAS# 755038-65-4
$70.00
N-[4-[4-(Cyclopropylmethyl)piperazin-1-yl]cyclohexyl]-4-[[(7R)-7-ethyl-5-methyl-6-oxo-8-propan-2-yl-7H-pteridin-2-yl]amino]-3-methoxybenzamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4818-5mg-EA
Volasertib, Polo-like Kinase 1 inhibitor, 5mg, CAS# 755038-65-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsVolasertib is an extremely potent and selective inhibitor (IC50's: Plk1= 0.87 nM, Plk2 = 5 nM, Plk3 = 56 nM) of Polo-like kinase 1, a critical controller of multiple essential steps of mitosis.1 It has shown efficacy in multiple solid xenograft tumors models1 and in clinical studies in patients with acute myeloid leukemia2. Volasertib has also been shown to potently inhibit BRD43 (Kd = 79 nM3, IC50's bromodomains 1 and 2 of BRD4 = 300 and 770 nM respectively2).
CAS Number: 755038-65-4
Manufacturer Part Number/SKU: 10-4818-5mg-EA
Tags: Focus Biomolecules