GSK2656157, Potent and selective PERK inhibitor, 5mg, CAS# 1337532-29-2
$40.00
1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4855-5mg-EA
GSK2656157, Potent and selective PERK inhibitor, 5mg, CAS# 1337532-29-2 is available to buy in increments of 1
Product Details
Download Details and SpecificationsPotent (IC50 = 0.9 nM) and selective (over 300 kinases) inhibitor of protein kinase RNA-like endoplasmic reticulum kinase (PERK).1,2 Inhibited growth of multiple human tumor xenografts in mice. GSK2656157 has also been found to potently inhibit RIPK1 (IC50 = 69 nM) and TNF-mediated RIPK1 kinase-dependent cell death in mouse embryonic fibroblasts.3 It prevented the loss of dendritic spines and rescued memory deficits after traumatic brain injury.4 GSK2656157 also enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes mellitus.5
CAS Number: 1337532-29-2
Manufacturer Part Number/SKU: 10-4855-5mg-EA
Tags: Focus Biomolecules