E7820, RBM39 molecular glue, 5mg, CAS# 289483-69-8
$50.00
N-(3-Cyano-4-methyl-1H-indol-7-yl)-3-cyanobenzenesulfonamide Purity: 98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3935-5mg-EA
E7820, RBM39 molecular glue, 5mg, CAS# 289483-69-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsE7820 is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ß1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression.2 E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERα (RBM39) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines.3,4 E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress.5
CAS Number: 289483-69-8
Manufacturer Part Number/SKU: 10-3935-5mg-EA
Tags: Focus Biomolecules