20(S)-Hydroxycholesterol, Smoothened activator, 1mg, CAS# 516-72-3
$40.00
5-Cholesten-3ß Purity: 20a-diol Purity: 98% by TLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4540-1mg-EA
20(S)-Hydroxycholesterol, Smoothened activator, 1mg, CAS# 516-72-3 is available to buy in increments of 1
Product Details
Download Details and Specifications20-(S)-Hydroxycholesterol is an endogenous ligand for the LXR receptor.1 It has anti-adipogenic and pro-osteogenic effects in mesenchymal stem cells mediated via a non-LXR dependent pathway.2 The osteogenic effects of 20-(S)-hydroxycholesterol have been shown to be mediated by activation of hedgehog signaling and expression of genes associated with Notch signaling.3 Activation of Hedgehog is mediated via binding of 20(S)-hydroxycholesterol to Smoothened at a site distinct from the cyclopamine binding site.4,5
CAS Number: 516-72-3
Manufacturer Part Number/SKU: 10-4540-1mg-EA
Tags: Focus Biomolecules