BMH-21, RNA polymerase I inhibitor, 5mg, CAS# 896705-16-1
$52.00
N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide Purity: >98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-5688-5mg-EA
BMH-21, RNA polymerase I inhibitor, 5mg, CAS# 896705-16-1 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 µM in U2OS cells, but not Pols II or III, blocking transcription elongation without inducing the DNA damage response.1-3 Inhibition disengages Pol I from chromatin, resulting in proteasome-dependent destruction of Pol I subunit RPA194.4 At nanomolar concentrations it also activates p53 in A375 cells.5
CAS Number: 896705-16-1
Manufacturer Part Number/SKU: 10-5688-5mg-EA
Tags: Focus Biomolecules