BAY 87-2243, HIF-1 / Mitochondrial complex I inhibitor, 5mg, CAS# 1227158-85-1
$65.00
5-[1-[[2-(4-Cyclopropylpiperazin-1-yl)pyridin-4-yl]methyl]-5-methylpyrazol-3-yl]-3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazole Purity: 98% by HPLC NMR (Conforms) Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4910-5mg-EA
BAY 87-2243, HIF-1 / Mitochondrial complex I inhibitor, 5mg, CAS# 1227158-85-1 is available to buy in increments of 1
Product Details
Download Details and SpecificationsBAY 87-2243 potently inhibits HIF-1 reporter gene activity (IC50 = 0.7 nM) and CA9 protein expression (IC50 = 2.0 nM).1 It inhibited HIF-1a and HIF-2a protein accumulation in hypoxic H460 cells and reduced tumor weight in nude mice inoculated with H460 cells. BAY 87-2243 potently inhibits mitochondrial complex I activity (IC50 = 10 nM in mitochondria isolated from PC3 cells) leading to its HIF-1 effects. It has no effect on mitochondrial complex III. BAY 87-2243 reduced melanoma tumor growth via its targeting of mitochondrial complex I.2,3
CAS Number: 1227158-85-1
Manufacturer Part Number/SKU: 10-4910-5mg-EA
Tags: Focus Biomolecules