AZD1208, pan-PIM kinase inhibitor, 5mg, CAS# 1204144-28-4
$55.00
(5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4781-5mg-EA
AZD1208, pan-PIM kinase inhibitor, 5mg, CAS# 1204144-28-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsAZD1208 is a highly selective and potent pan-PIM kinase inhibitor (IC50 = 3 nM PIM1; 150 nM PIM2; 9 nM PIM3).1 Displayed efficacy in models of acute myeloid leukemia2, prostate cancer3, and triple-negative breast cancer4. Combination treatment of AZD1208 and imatinib eliminated chronic myelogenous leukemia stem cells in cell culture and a patient-derived mouse xenograft model.5 It improved immunotherapeutic antitumor T-cell response6 and disrupted the myeloid cell-mediated immunosuppressive tumor microenvironment increasing T-cell-mediated antitumor immunity.
CAS Number: 1204144-28-4
Manufacturer Part Number/SKU: 10-4781-5mg-EA
Tags: Focus Biomolecules