Crenolanib, PDGFR and FLT3 inhibitor, 25mg, CAS# 670220-88-9
$195.00
1-[2-[5-[(3-Methyloxetan-3-yl)methoxy]benzimidazole-1-yl]quinoline-8-yl]piperidin-4-amine Purity: 97% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4782-25mg-EA
Crenolanib, PDGFR and FLT3 inhibitor, 25mg, CAS# 670220-88-9 is available to buy in increments of 1
Product Details
Download Details and SpecificationsCrenolanib is a potent inhibitor of PDGFR (Kd for α = 2.1 nM; ß = 3.2 nM) and FLT3 (Kd = 0.74 nM).1 Crenolanib is a type I inhibitor binding only to the active kinase conformation. It showed potent activity against imatinib-resistant PDGFRα mutations D842I, D842V, D842Y, DI842-843M, and deletion I8432 as well as FLT3/ITD and FLT3/D835 mutants3. Crenolanib acted synergistically with FLT3-CAR T-cells in a FLT3-ITD+ AML murine xenograft model.4
CAS Number: 670220-88-9
Manufacturer Part Number/SKU: 10-4782-25mg-EA
Tags: Focus Biomolecules