Alisertib, Aurora A inhibitor; Destablizes Myc, 5mg, CAS# 1028486-01-2
$65.00
4-{[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}-2-methoxybenzoic acid Purity: 98% by HPLC Purity: NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4124-5mg-EA
Alisertib, Aurora A inhibitor; Destablizes Myc, 5mg, CAS# 1028486-01-2 is available to buy in increments of 1
Product Details
Download Details and SpecificationsAlisertib (MLN8237) is a highly selective and potent (IC50 = 1 nM) cell permeable inhibitor of Aurora A with off-target binding at GABAA (IC50 = 490 nM).1 It disrupts the Aurora A-Myc complex leading to Myc degradation2 in Myc amplified neuroblastomas3 and p53-mutant human hepatocellular carcinoma cell4. Alisertib has been found to induce apoptosis and autophagy in breast cancer5 and melanoma6 cells via suppression of activation of the p38 MAPK pathway.
CAS Number: 1028486-01-2
Manufacturer Part Number/SKU: 10-4124-5mg-EA
Tags: Focus Biomolecules