Acalabrutinib, BTK inhibitor, 5mg, CAS# 1420477-60-6
$45.00
4-[8-Amino-3-[(2S)-1-but-2-ynoylpyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-N-pyridin-2-ylbenzamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4806-5mg-EA
Acalabrutinib, BTK inhibitor, 5mg, CAS# 1420477-60-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsAcalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton's tyrosine kinase (BTK).1 Improved target selectivity (especially against TEC family kinases and EGFR) decreased the number of serious side effects observed with Ibrutinib.2 Acalabrutinib significantly inhibits BCR signaling, inhibits tumor proliferation, and reduces tumor burden.3 Clinically useful agent for treating B-cell cancers. BTK has also been shown to have a role in modulating the innate immune system, especially in dendritic cells and macrophages, suggesting a possible role in immunotherapy.4
CAS Number: 1420477-60-6
Manufacturer Part Number/SKU: 10-4806-5mg-EA
Tags: Focus Biomolecules