AAL-993, VEGFR inhibitor, 5mg, CAS# 269390-77-4
$75.00
2-[(4-Pyridyl)methyl]amino-N-[3-(trifluoromethyl)phenyl]benzamide Purity: 98% by TLC [60% ethyl acetate in hexane; Rf = 0.36] NMR conforms Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1034-5mg-EA
AAL-993, VEGFR inhibitor, 5mg, CAS# 269390-77-4 is available to buy in increments of 1
Product Details
Download Details and SpecificationsInhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-ß, cKit, and CSF-1R are also inhibited at higher concentrations (IC50's 640 nM, 236 nM and 380 nM respectively). Screening studies have shown no inhibitory activity against a range of other kinases. X-Ray crystallography has shown that AAL-993 binds to the catalytic domain of VEGFR-2 when the protein is in an inactive conformation. Cell permeable, active in vivo and in whole animal studies.
CAS Number: 269390-77-4
Manufacturer Part Number/SKU: 10-1034-5mg-EA
Tags: Focus Biomolecules