6-Thioguanine, Anticancer agent / downregulates DNMT1, 100mg, CAS# 154-42-7
$30.00
2-Amino-6-mercaptopurine Purity: 96% by HPLC NMr (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1282-100mg-EA
6-Thioguanine, Anticancer agent / downregulates DNMT1, 100mg, CAS# 154-42-7 is available to buy in increments of 1
Product Details
Download Details and SpecificationsAfter incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.
CAS Number: 154-42-7
Manufacturer Part Number/SKU: 10-1282-100mg-EA
Tags: Focus Biomolecules