XIB4035, GFRα1 agonist, 5mg, CAS# 10023-54-8
$60.00
(E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine 3(H3PO4) Purity: 98% by TLC Purity: NMR (Conforms) Store RT Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-1486-5mg-EA
XIB4035, GFRα1 agonist, 5mg, CAS# 10023-54-8 is available to buy in increments of 1
Product Details
Download Details and SpecificationsA novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson's disease therapeutics.4
CAS Number: 10023-54-8
Manufacturer Part Number/SKU: 10-1486-5mg-EA
Tags: Focus Biomolecules