WX-02-23, Spliceosome/FOXA1 modulator, 5mg, CAS# 2929223-35-6
$90.00
1-((1R,3S)-1-(benzo[d][1,3]dioxol-5-yl)-3-(morpholine-4-carbonyl)-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)prop-2-en-1-one Purity: >98% by HPLC Purity: NMR (conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-3969-5mg-EA
WX-02-23, Spliceosome/FOXA1 modulator, 5mg, CAS# 2929223-35-6 is available to buy in increments of 1
Product Details
Download Details and SpecificationsWX-02-23 is a spliceosome modulator. It binds to the spliceosome factor SF3B1 stabilizing a spliceosome state with enhanced binding to DDX42. WX-02-23 displayed anti-proliferative effects in Panc 05.04 and Panc 04.03 cells.1 WX-02-23 also modulates the pioneer transcription factor FOXA1 via covalent binding to Cysteine 258 in a DNA-dependent manner (EC50 = 2 µM FOXA1; 12 µM FOXA1-FKHD). It alters activity via relaxation of FOXA1s DNA-binding motif changing chromatin accessibility.2
CAS Number: 2929223-35-6
Manufacturer Part Number/SKU: 10-3969-5mg-EA
Tags: Focus Biomolecules