WP1066, JAK/STAT3 inhibitor, 10mg, CAS# 857064-38-1
$79.00
(E)-3-(6-Pyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide Purity: 98% by HPLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4831-10mg-EA
WP1066, JAK/STAT3 inhibitor, 10mg, CAS# 857064-38-1 is available to buy in increments of 1
Product Details
Download Details and SpecificationsWP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma U87-MG (IC50 = 5.6µM) and U373-MG (IC50 = 3.7µM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells.4,5 WP1066 abrogated PD-L1 expression in lymphoma cell lines.6
CAS Number: 857064-38-1
Manufacturer Part Number/SKU: 10-4831-10mg-EA
Tags: Focus Biomolecules