URMC-099, Mixed-lineage kinase 3 inhibitor, 25mg, CAS# 1229582-33-5
$190.00
3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine Purity: 98% by TLC NMR (Conforms) Store -20°C Ship RT (1 per EA )
Manufacturer: Focus Biomolecules
SKU
10-4012-25mg-EA
URMC-099, Mixed-lineage kinase 3 inhibitor, 25mg, CAS# 1229582-33-5 is available to buy in increments of 1
Product Details
Download Details and SpecificationsURMC-099 is a potent (IC50 = 14 nM), brain penetrant mixed-lineage kinase 3 inhibitor (MLK3). It also potently inhibits FLT3 (4 nM in vitro, but 560 nM in vivo), LRRK2 (11 nM), and ABL1 (3 nM).1 URMC-099 displayed neuroprotective effects in HIV-associated neurocognitive disorders2 and facilitated microglial amyloid-b degradation and clearance in mouse models.3,4 URMC-099 increased CD8+ T cells in mice and increased the CD8+GZMB+ T cell population in blood mononuclear cells isolated from breast cancer patients.5
CAS Number: 1229582-33-5
Manufacturer Part Number/SKU: 10-4012-25mg-EA
Tags: Focus Biomolecules